ABSTRACT
Background: We just right were carrying out a multicenter cohort study about ICH when COVID-19 broke out in Wuhan，and we wondered whether COVID-19 pandemic was associated with the manifestations and outcomes of intracerebral hemorrhage (ICH). Methods: : Acute ICH patients before (1/12/2018-30/11/2019) and during COVID-19(1/12/2019-30/11/2020) pandemic at 31 centers in China, were entered into the analysis. Demographic information, clinical manifestations and outcomes were collected and compared between the two groups. Results: : From December 1, 2018 to November 30, 2020, a total of 3460 patients with ICH were enrolled and eventually analyzed. Results showed that patients with ICH were more likely to be older, have higher systolic blood pressure (BP) (P<0.001), diastolic-BP (P=0.002), higher admission NIHSS score (P=0.039) and higher fasting blood glucose (P=0.003) during COVID-19 pandemic compared with before. After adjusting age, gender, COVID-19 pandemic was associated with 3-month poor outcome (OR = 1.206, 95%CI: 1.043-1.395) and 3-month mortality (OR = 1.711, 95%CI: 1.428-2.050) after ICH onset. Conclusions: : COVID-19 pandemic deteriorated the manifestations and outcomes of ICH.
Subject(s)
Cerebral Hemorrhage , Hypotension , COVID-19ABSTRACT
Carsharing is regarded as a new mode of transportation that can meet the diversity of travel demands. Carsharing systems have different operating modes, and one-way systems are more widely used since cars can be dropped off at any station. However, their planning involves a series of joint decisions regarding the number, size, and location of stations, as well as the fleet size. This paper develops a data-driven mixed-integer linear programming (MILP) model for planning one-way carsharing systems that consider the spatial distribution of demand and the interacting decisions between stations. The characteristics of existing stations and their spatiotemporal correlations are an important part of the model. To solve the MILP model, the extension of the Benders decomposition algorithm is adopted. The practicality of the proposed approach is demonstrated in a case study in Beijing, China. The results show that the existing planning of carsharing could result in a serious waste of resources. In contrast, the proposed method can obtain effective results in a reasonable time. The location results corresponding to a different rate of satisfied demand show that increasing the parking spots to improve the interaction between stations can effectively reduce the cost of operations. It should be noted that this paper only considers the benefit of operators. Future works will be carried out to optimize the one-way carsharing system by considering the benefits of operators, as well as the benefits of users and society. In addition, the impact of COVID-19 will be taken into account in future modeling and case studies.
ABSTRACT
Actin-binding protein Anillin plays a pivotal role in regulating cytokinesis during the cell cycle, and involves in tumorigenesis and progress. However, the exact regulation mechanism of Anillin in human hepatocellular carcinoma (HCC) remains largely unknown. In this study, we examined and verified the anomalous high expression of Anillin in both HCC patients'specimens and HCC cell lines. High expression of Anillin is associated with dismal clinicopathologic features of HCC patients and poor prognosis. We conducted loss-of and gain-of function studies in HCC Hep3B cells. Anillin presented a significantly facilitating effect on cell proliferation in vitro and induced remarkable tumor growth in vivo. We found that the over-expression of Anillin was driven by a potential axis of miR-138/SOX4. Transcription factor SOX4 presented a high expression profile positive correlated with Anillin, and ChIP assay validated the interaction between SOX4 and the specific sequence of the promoter region of Anillin gene. While, we verified miR-138 as an upstream regulator of SOX4, which is abrogated in HCC cells and exerts degenerating effect on SOX4 mRNA. In our conclusion, Anillin facilitates the cell proliferation and enhances tumor growth of HCC, and is modulated by miR-138/SOX4 axis which regulates the transcriptional activity of Anillin. Findings above demonstrate us a probable axis for HCC diagnosis and treatment. SUMMARY OF THE MAIN POINT: Anillin facilitates the cell proliferation and enhances tumor growth in HCC. The transcriptional activity of Anillin is modulated by miR-138/SOX4 axis. Findings above demonstrate us a probable axis for HCC diagnosis and treatment.
ABSTRACT
In view of the fact that the 2019-nCoV has spread to most countries in the world, it is necessary to make scientific and well-founded predictions of the current pandemic situation caused by the virus worldwide, which are conducive to public, social and government responses that mitigate and appropriately address the pandemic. We collected data from provinces with more than 200 cases in China and from eight other countries. Our analyses showed that the disease duration has no correlation with the number of patients, with r = 0.184. The number of deaths was not correlated to the disease duration, with r = 0.242. However, a positive correlation between the days of disease duration and infection rate, with a r = 0.626. Furthermore, there is a strong positive correlation between the disease duration and total death rate, with a r = 0.707. Using death rate of first 25 days, we obtained a positive relationship with a r value of 0.597. Based on the data from first 25 days, the minimum and maximum days of COVID-19 pandemic duration of eight countries was estimated between days of 37 and 114 days.